Research summary

During my PhD,  I have been working on developing protein and peptide inhibitors of a range of protein-protein interactions as potential cancer therapeutics. For the protein inhibitors, I have focused on engineering new function into the loops of repeat proteins to form a new class of biotherapeutics. Repeat proteins are ideal for such projects due to their high stability, meaning that we can heavily engineer these proteins and still produce a very stable protein. Using this approach, I have been able to develop low nanomolar affinity inhibitors to block the interaction between Kelch-like ECH-associated protein 1 (Keap1) and Nuclear factor erythroid 2-related factor 2 (Nrf2).

Publications

4. Exploring new strategies for grafting binding peptides into protein loops with a consensus-designed repeat scaffold                                                           

Sarah K. Madden et al. Protein Science, 2019.

3. Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

Akane Kawamura et al. Nature Communications, 2017.

 

2. Studies on the Catalytic Domains of Multiple JmjC Oxygenases Using Peptide Substrates

Sophie T. Williams et al. Epigenetics, 2014.

 

1. Human UTY (KDM6C) is a Male-Specific Nϵ-Methyl Lysyl-Demethylase

 Louise J. Walport et al. Journal of Biological Chemistry, 2014.

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